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As a highly potent, natural anticoagulant, heparin is well known as an antithrombotic agent, and it has been shown to inhibit smooth muscle cell proliferation. INTERGARD Heparin grafts incorporate biologically active heparin on the fabric of the graft. A prospective, randomized clinical trial demonstrated significantly higher patency rates and significantly lower amputation rates compared with PTFE1.

Made of collagen-coated heparin bonded polyester, INTERGARD Heparin grafts are available in Knitted and UltraThin configurations, offering the advantages of heparin for a variety of vascular procedures.

A unique drug/device combination, INTERGARD Heparin has several advantages:

  • Proprietary heparin-bonding process designed to allow the antithrombotic and antiproliferative properties of biologically active heparin to be available locally at the graft surface
  • Higher patency rates compared to PTFE1
  • Significantly lower amputation rates than PTFE1
  • Validated for intended use with rifampicin loading

[1] Devine C, McCollum C; North West Femoro-Popliteal Trial Participants. Heparin-bonded Dacron or polytetrafluorethylene for femoropopliteal bypass: Five-year results of a prospective randomized multicenter clinical trial. J Vasc Surg. 2004 Nov;40(5):924-931.

  • Material
    • Collagen-coated heparin-bonded polyester graft
    • Available in Knitted and UltraThin configurations
    • Water permeability: ≤ 5 mL . cm-2. min-1
  • Healing: Excellent graft healing and tissue incorporation1
  • Handling: Superb handling and host vessel conformability
  • Hemostasis: No suture hole bleeding

[1] Becquemin JP, Riff Y, Kovarsky S, et al. Evaluation of a polyester collagen-coated heparin bonded vascular graft. J Cardiovasc Surg 1997 Feb;38(1):7-14.


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